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2025
2025
Structural basis for TORC2 activation.
Zou, L; Tettamanti, MG; Bergmann, A; Loewith , R; Tafur , L.
bioRxiv preprint
DOI: https://doi.org/10.1101/2025.07.02.662585
A dynamic feedback loop between retrograde sterol transport and TORC2 controls adaptation of the plasma membrane to stress
Tettamanti, MG; Nowak, P; Kusmider, B; Kefauver, JM; Mercier, V; Roux, A; Loewith, R.
EMBO J. 2025
DOI: https://doi.org/10.1038/s44318-025-00618-7
Structure and function of the yeast amino acid-sensing SEAC-EGOC supercomplex.
Tafur, L; Bonadei, L; Zheng, Y; Loewith, R.
bioRxiv preprint
DOI: https://doi.org/10.1101/2024.10.05.616782
2024
2024
Small Molecule Modulator of the mTORC2 Pathway Discovered from a DEL Library Designed to Bind to Pleckstrin Homology Domains.
Gonse A, Gajić J, Daguer JP, Barluenga S, Loewith R, Winssinger N
ACS Chem Biol, 2024 Nov 12;
DOI: 10.1021/acschembio.4c00597
Cryo-EM architecture of a near-native stretch-sensitive membrane microdomain.
Kefauver JM, Hakala M, Zou L, Alba J, Espadas J, Tettamanti MG, Gajić J, Gabus C, Campomanes P, Estrozi LF, Sen NE, Vanni S, Roux A, Desfosses A, Loewith R
Nature, 2024 Aug; 632 (8025): 664-671
DOI: 10.1038/s41586-024-07720-6
2023
2023
EGOC inhibits TOROID polymerization by structurally activating TORC1.
Prouteau M, Bourgoint C, Felix J, Bonadei L, Sadian Y, Gabus C, Savvides SN, Gutsche I, Desfosses A, Loewith R
Nat Struct Mol Biol, 2023 Mar; 30 (3): 273-285
DOI: 10.1038/s41594-022-00912-6
Dynamic metabolome profiling uncovers potential TOR signaling genes.
Reichling S, Doubleday PF, Germade T, Bergmann A, Loewith R, Sauer U, Holbrook-Smith D
Elife, 2023 Jan 4; 12
DOI: 10.7554/eLife.84295
2022
2022
Ultrastructure expansion microscopy reveals the cellular architecture of budding and fission yeast.
Hinterndorfer K, Laporte MH, Mikus F, Tafur L, Bourgoint C, Prouteau M, Dey G, Loewith R, Guichard P, Hamel V
J Cell Sci, 2022 Dec 15; 135 (24)
DOI: 10.1242/jcs.260240
Cryo-EM structure of the SEA complex.
Tafur L, Hinterndorfer K, Gabus C, Lamanna C, Bergmann A, Sadian Y, Hamdi F, Kyrilis FL, Kastritis PL, Loewith R
Nature, 2022 Nov; 611 (7935): 399-404
DOI: 10.1038/s41586-022-05370-0
2021
2021
Chemical-Biology-derived in vivo Sensors: Past, Present, and Future.
Loewith R, Roux A, Pertz O
Chimia (Aarau), 2021 Dec 22; 75 (12): 1017-1021
Flipper Probes for the Community.
Assies L, García-Calvo J, Piazzolla F, Sanchez S, Kato T, Reymond L, Goujon A, Colom A, López-Andarias J, Straková K, Mahecic D, Mercier V, Riggi M, Jiménez-Rojo N, Roffay C, Licari G, Tsemperouli M, Neuhaus F, Fürstenberg A, Vauthey E, Hoogendoorn S, Gonzalez-Gaitan M, Zumbuehl A, Sugihara K, Gruenberg J, Riezman H, Loewith R, Manley S, Roux A, Winssinger N, Sakai N, Pitsch S, Matile S
Chimia (Aarau), 2021 Dec 22; 75 (12): 1004-1011
Passive coupling of membrane tension and cell volume during active response of cells to osmosis.
Roffay C, Molinard G, Kim K, Urbanska M, Andrade V, Barbarasa V, Nowak P, Mercier V, García-Calvo J, Matile S, Loewith R, Echard A, Guck J, Lenz M, Roux A
Proc Natl Acad Sci U S A, 2021 Nov 23; 118 (47)
Identification of a Covalent Importin-5 Inhibitor, Goyazensolide, from a Collective Synthesis of Furanoheliangolides.
Liu W, Patouret R, Barluenga S, Plank M, Loewith R, Winssinger N
ACS Cent Sci, 2021 Jun 23; 7 (6): 954-962
DOI: 10.1021/acscentsci.1c00056
Phosphoproteomic Effects of Acute Depletion of PP2A Regulatory Subunit Cdc55.
Plank M, Berti M, Loewith R
Proteomics, 2021 Jan; 21 (1): e2000166
2020
2020
Resolving the Communication GAPs Upstream of TORC1.
Puschmann R, Loewith R
Dev Cell, 2020 Nov 9; 55 (3): 253-254
DOI: 10.1016/j.devcel.2020.10.007
TOR complex 2 (TORC2) signaling and the ESCRT machinery cooperate in the protection of plasma membrane integrity in yeast.
Schmidt O, Weyer Y, Sprenger S, Widerin MA, Eising S, Baumann V, Angelova M, Loewith R, Stefan CJ, Hess MW, Fröhlich F, Teis D
J Biol Chem, 2020 Aug 21; 295 (34): 12028-12044
Structural Insights into TOR Signaling.
Tafur L, Kefauver J, Loewith R
Genes (Basel), 2020 Aug 4; 11 (8)
The flipside of the TOR coin - TORC2 and plasma membrane homeostasis at a glance.
Riggi M, Kusmider B, Loewith R
J Cell Sci, 2020 May 11; 133 (9)
DOI: 10.1242/jcs.242040
Chemical Genetics of AGC-kinases Reveals Shared Targets of Ypk1, Protein Kinase A and Sch9.
Plank M, Perepelkina M, Müller M, Vaga S, Zou X, Bourgoint C, Berti M, Saarbach J, Haesendonckx S, Winssinger N, Aebersold R, Loewith R
Mol Cell Proteomics, 2020 Apr; 19 (4): 655-671
The Aspartic Protease Ddi1 Contributes to DNA-Protein Crosslink Repair in Yeast.
Serbyn N, Noireterre A, Bagdiul I, Plank M, Michel AH, Loewith R, Kornmann B, Stutz F
Mol Cell, 2020 Mar 5; 77 (5): 1066-1079.e9
DOI: 10.1016/j.molcel.2019.12.007
2019
2019
Tricalbin-Mediated Contact Sites Control ER Curvature to Maintain Plasma Membrane Integrity.
Collado J, Kalemanov M, Campelo F, Bourgoint C, Thomas F, Loewith R, Martínez-Sánchez A, Baumeister W, Stefan CJ, Fernández-Busnadiego R
Dev Cell, 2019 Nov 18; 51 (4): 476-487.e7
DOI: 10.1016/j.devcel.2019.10.018
TORC2 controls endocytosis through plasma membrane tension.
Riggi M, Bourgoint C, Macchione M, Matile S, Loewith R, Roux A
J Cell Biol, 2019 Jul 1; 218 (7): 2265-2276
Sphingolipids and membrane targets for therapeutics.
Loewith R, Riezman H, Winssinger N
Curr Opin Chem Biol, 2019 Jun; 50 : 19-28
DOI: 10.1016/j.cbpa.2019.02.015
TOR Signaling Is Going through a Phase.
Prouteau M, Loewith R
Cell Metab, 2019 May 7; 29 (5): 1019-1021
DOI: 10.1016/j.cmet.2019.04.010
2018
2018
Regulation of Cellular Metabolism through Phase Separation of Enzymes.
Prouteau M, Loewith R
Biomolecules, 2018 Dec 3; 8 (4)
DOI: 10.3390/biom8040160
Decrease in plasma membrane tension triggers PtdIns(4,5)P(2) phase separation to inactivate TORC2.
Riggi M, Niewola-Staszkowska K, Chiaruttini N, Colom A, Kusmider B, Mercier V, Soleimanpour S, Stahl M, Matile S, Roux A, Loewith R
Nat Cell Biol, 2018 Sep; 20 (9): 1043-1051
DOI: 10.1038/s41556-018-0150-z
Target of rapamycin complex 2-dependent phosphorylation of the coat protein Pan1 by Akl1 controls endocytosis dynamics in Saccharomyces cerevisiae.
Bourgoint C, Rispal D, Berti M, Filipuzzi I, Helliwell SB, Prouteau M, Loewith R
J Biol Chem, 2018 Aug 3; 293 (31): 12043-12053
Systematic analysis of complex genetic interactions.
Kuzmin E, VanderSluis B, Wang W, Tan G, Deshpande R, Chen Y, Usaj M, Balint A, Mattiazzi Usaj M, van Leeuwen J, Koch EN, Pons C, Dagilis AJ, Pryszlak M, Wang JZY, Hanchard J, Riggi M, Xu K, Heydari H, San Luis BJ, Shuteriqi E, Zhu H, Van Dyk N, Sharifpoor S, Costanzo M, Loewith R, Caudy A, Bolnick D, Brown GW, Andrews BJ, Boone C, Myers CL
Science, 2018 Apr 20; 360 (6386)
2017
2017
Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2.
Karuppasamy M, Kusmider B, Oliveira TM, Gaubitz C, Prouteau M, Loewith R, Schaffitzel C
Nat Commun, 2017 Nov 23; 8 (1): 1729
DOI: 10.1038/s41467-017-01862-0
TORC1 organized in inhibited domains (TOROIDs) regulate TORC1 activity.
Prouteau M, Desfosses A, Sieben C, Bourgoint C, Lydia Mozaffari N, Demurtas D, Mitra AK, Guichard P, Manley S, Loewith R
Nature, 2017 Oct 12; 550 (7675): 265-269
DOI: 10.1038/nature24021
Tensing Up for Lipid Droplet Formation.
Roux A, Loewith R
Dev Cell, 2017 Jun 19; 41 (6): 571-572
DOI: 10.1016/j.devcel.2017.06.001
A pathway of targeted autophagy is induced by DNA damage in budding yeast.
Eapen VV, Waterman DP, Bernard A, Schiffmann N, Sayas E, Kamber R, Lemos B, Memisoglu G, Ang J, Mazella A, Chuartzman SG, Loewith RJ, Schuldiner M, Denic V, Klionsky DJ, Haber JE
Proc Natl Acad Sci U S A, 2017 Feb 14; 114 (7): E1158-E1167
2016
2016
Reciprocal Regulation of Target of Rapamycin Complex 1 and Potassium Accumulation.
Primo C, Ferri-Blázquez A, Loewith R, Yenush L
J Biol Chem, 2017 Jan 13; 292 (2): 563-574
Dual action antifungal small molecule modulates multidrug efflux and TOR signaling.
Shekhar-Guturja T, Gunaherath GM, Wijeratne EM, Lambert JP, Averette AF, Lee SC, Kim T, Bahn YS, Tripodi F, Ammar R, Döhl K, Niewola-Staszkowska K, Schmitt L, Loewith RJ, Roth FP, Sanglard D, Andes D, Nislow C, Coccetti P, Gingras AC, Heitman J, Gunatilaka AA, Cowen LE
Nat Chem Biol, 2016 Oct; 12 (10): 867-875
TORC2 Structure and Function.
Gaubitz C, Prouteau M, Kusmider B, Loewith R
Trends Biochem Sci, 2016 Jun; 41 (6): 532-545
DOI: 10.1016/j.tibs.2016.04.001
A Signaling Lipid Associated with Alzheimer's Disease Promotes Mitochondrial Dysfunction.
Kennedy MA, Moffat TC, Gable K, Ganesan S, Niewola-Staszkowska K, Johnston A, Nislow C, Giaever G, Harris LJ, Loewith R, Zaremberg V, Harper ME, Dunn T, Bennett SAL, Baetz K
Sci Rep, 2016 Jan 13; 6 : 19332
DOI: 10.1038/srep19332
2015
2015
TORC1 and TORC2 work together to regulate ribosomal protein S6 phosphorylation in Saccharomyces cerevisiae.
Yerlikaya S, Meusburger M, Kumari R, Huber A, Anrather D, Costanzo M, Boone C, Ammerer G, Baranov PV, Loewith R
Mol Biol Cell, 2016 Jan 15; 27 (2): 397-409
TOR Complexes and the Maintenance of Cellular Homeostasis.
Eltschinger S, Loewith R
Trends Cell Biol, 2016 Feb; 26 (2): 148-159
DOI: 10.1016/j.tcb.2015.10.003
Molecular Basis of the Rapamycin Insensitivity of Target Of Rapamycin Complex 2.
Gaubitz C, Oliveira TM, Prouteau M, Leitner A, Karuppasamy M, Konstantinidou G, Rispal D, Eltschinger S, Robinson GC, Thore S, Aebersold R, Schaffitzel C, Loewith R
Mol Cell, 2015 Jun 18; 58 (6): 977-988
DOI: 10.1016/j.molcel.2015.04.031
Target of Rapamycin Complex 2 Regulates Actin Polarization and Endocytosis via Multiple Pathways.
Rispal D, Eltschinger S, Stahl M, Vaga S, Bodenmiller B, Abraham Y, Filipuzzi I, Movva NR, Aebersold R, Helliwell SB, Loewith R
J Biol Chem, 2015 Jun 12; 290 (24): 14963-14978
2014
2014
Systematic lipidomic analysis of yeast protein kinase and phosphatase mutants reveals novel insights into regulation of lipid homeostasis.
da Silveira Dos Santos AX, Riezman I, Aguilera-Romero MA, David F, Piccolis M, Loewith R, Schaad O, Riezman H
Mol Biol Cell, 2014 Oct 15; 25 (20): 3234-3246
Roles for PI(3,5)P2 in nutrient sensing through TORC1.
Jin N, Mao K, Jin Y, Tevzadze G, Kauffman EJ, Park S, Bridges D, Loewith R, Saltiel AR, Klionsky DJ, Weisman LS
Mol Biol Cell, 2014 Apr; 25 (7): 1171-1185
A neurotoxic glycerophosphocholine impacts PtdIns-4, 5-bisphosphate and TORC2 signaling by altering ceramide biosynthesis in yeast.
Kennedy MA, Gable K, Niewola-Staszkowska K, Abreu S, Johnston A, Harris LJ, Reggiori F, Loewith R, Dunn T, Bennett SA, Baetz K
PLoS Genet, 2014 Jan; 10 (1): e1004010
DOI: 10.1371/journal.pgen.1004010
2013
2013
TORC2 signaling pathway guarantees genome stability in the face of DNA strand breaks.
Shimada K, Filipuzzi I, Stahl M, Helliwell SB, Studer C, Hoepfner D, Seeber A, Loewith R, Movva NR, Gasser SM
Mol Cell, 2013 Sep 26; 51 (6): 829-839
DOI: 10.1016/j.molcel.2013.08.019
Growth control: function follows form.
Loewith R
Curr Biol, 2013 Jul 22; 23 (14): R607-R609
DOI: 10.1016/j.cub.2013.05.048
2012
2012
Amino acid signaling in high definition.
Gaubitz C, Loewith R
Structure, 2012 Dec 5; 20 (12): 1993-1994
DOI: 10.1016/j.str.2012.11.006
Identification of a small molecule yeast TORC1 inhibitor with a multiplex screen based on flow cytometry.
Chen J, Young SM, Allen C, Seeber A, Péli-Gulli MP, Panchaud N, Waller A, Ursu O, Yao T, Golden JE, Strouse JJ, Carter MB, Kang H, Bologa CG, Foutz TD, Edwards BS, Peterson BR, Aubé J, Werner-Washburne M, Loewith RJ, De Virgilio C, Sklar LA
ACS Chem Biol, 2012 Apr 20; 7 (4): 715-722
DOI: 10.1021/cb200452r
Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis.
Berchtold D, Piccolis M, Chiaruttini N, Riezman I, Riezman H, Roux A, Walther TC, Loewith R
Nat Cell Biol, 2012 Apr 15; 14 (5): 542-547
DOI: 10.1038/ncb2480
2011
2011
Target of rapamycin (TOR) in nutrient signaling and growth control.
Loewith R, Hall MN
Genetics, 2011 Dec; 189 (4): 1177-1201
DOI: 10.1534/genetics.111.133363
Mitochondrial genomic dysfunction causes dephosphorylation of Sch9 in the yeast Saccharomyces cerevisiae.
Kawai S, Urban J, Piccolis M, Panchaud N, De Virgilio C, Loewith R
Eukaryot Cell, 2011 Oct; 10 (10): 1367-1369
DOI: 10.1128/EC.05157-11
Sch9 regulates ribosome biogenesis via Stb3, Dot6 and Tod6 and the histone deacetylase complex RPD3L.
Huber A, French SL, Tekotte H, Yerlikaya S, Stahl M, Perepelkina MP, Tyers M, Rougemont J, Beyer AL, Loewith R
EMBO J, 2011 Jul 5; 30 (15): 3052-3064
A brief history of TOR.
Loewith R
Biochem Soc Trans, 2011 Apr; 39 (2): 437-442
DOI: 10.1042/BST0390437
Chemical biology approaches to membrane homeostasis and function.
Takahashi-Umebayashi M, Pineau L, Hannich T, Zumbuehl A, Doval DA, Matile S, Heinis C, Turcatti G, Loewith R, Roux A, Reymond L, Johnsson K, Riezman H
Chimia (Aarau), 2011; 65 (11): 849-852
2010
2010
Phosphoproteomic analysis reveals interconnected system-wide responses to perturbations of kinases and phosphatases in yeast.
Bodenmiller B, Wanka S, Kraft C, Urban J, Campbell D, Pedrioli PG, Gerrits B, Picotti P, Lam H, Vitek O, Brusniak MY, Roschitzki B, Zhang C, Shokat KM, Schlapbach R, Colman-Lerner A, Nolan GP, Nesvizhskii AI, Peter M, Loewith R, von Mering C, Aebersold R
Sci Signal, 2010 Dec 21; 3 (153): rs4
DOI: 10.1126/scisignal.2001182
Profiling a Selective Probe for RTG Branch of Yeast TORC1 Signaling Pathway.
Chen J, Young SM, Allen C, Waller A, Ursu O, Strouse JJ, Yao T, Golden JE, Peterson BR, Foutz TD, Chavez SE, Perez D, Evangelisti AM, Garcia MJ, Bologa CG, Carter MB, Salas VM, Oprea TI, Edwards BS, Panchaud N, De Virgilio C, Seeber A, Loewith R, Manzanilla E, Werner-Washburne M, Aubé J, Sklar LA
In: Probe Reports from the NIH Molecular Libraries Program, 2010;
2009
2009
The Vam6 GEF controls TORC1 by activating the EGO complex.
Binda M, Péli-Gulli MP, Bonfils G, Panchaud N, Urban J, Sturgill TW, Loewith R, De Virgilio C
Mol Cell, 2009 Sep 11; 35 (5): 563-573
DOI: 10.1016/j.molcel.2009.06.033
Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis.
Huber A, Bodenmiller B, Uotila A, Stahl M, Wanka S, Gerrits B, Aebersold R, Loewith R
Genes Dev, 2009 Aug 15; 23 (16): 1929-1943
DOI: 10.1101/gad.532109
Functional interactions between sphingolipids and sterols in biological membranes regulating cell physiology.
Guan XL, Souza CM, Pichler H, Dewhurst G, Schaad O, Kajiwara K, Wakabayashi H, Ivanova T, Castillon GA, Piccolis M, Abe F, Loewith R, Funato K, Wenk MR, Riezman H
Mol Biol Cell, 2009 Apr; 20 (7): 2083-2095
Sfp1 interaction with TORC1 and Mrs6 reveals feedback regulation on TOR signaling.
Lempiäinen H, Uotila A, Urban J, Dohnal I, Ammerer G, Loewith R, Shore D
Mol Cell, 2009 Mar 27; 33 (6): 704-716
DOI: 10.1016/j.molcel.2009.01.034
Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2.
Feldman ME, Apsel B, Uotila A, Loewith R, Knight ZA, Ruggero D, Shokat KM
PLoS Biol, 2009 Feb 10; 7 (2): e38
DOI: 10.1371/journal.pbio.1000038
Arsenic toxicity to Saccharomyces cerevisiae is a consequence of inhibition of the TORC1 kinase combined with a chronic stress response.
Hosiner D, Lempiäinen H, Reiter W, Urban J, Loewith R, Ammerer G, Schweyen R, Shore D, Schüller C
Mol Biol Cell, 2009 Feb; 20 (3): 1048-1057
2008
2008
Caffeine extends yeast lifespan by targeting TORC1.
Wanke V, Cameroni E, Uotila A, Piccolis M, Urban J, Loewith R, De Virgilio C
Mol Microbiol, 2008 Jul; 69 (1): 277-285
DOI: 10.1111/j.1365-2958.2008.06292.x
2007
2007
Sch9 is a major target of TORC1 in Saccharomyces cerevisiae.
Urban J, Soulard A, Huber A, Lippman S, Mukhopadhyay D, Deloche O, Wanke V, Anrather D, Ammerer G, Riezman H, Broach JR, De Virgilio C, Hall MN, Loewith R
Mol Cell, 2007 Jun 8; 26 (5): 663-674
DOI: 10.1016/j.molcel.2007.04.020
2006
2006
Mutual antagonism of target of rapamycin and calcineurin signaling.
Mulet JM, Martin DE, Loewith R, Hall MN
J Biol Chem, 2006 Nov 3; 281 (44): 33000-33007
Cell growth control: little eukaryotes make big contributions.
De Virgilio C, Loewith R
Oncogene, 2006 Oct 16; 25 (48): 6392-6415
A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling.
Knight ZA, Gonzalez B, Feldman ME, Zunder ER, Goldenberg DD, Williams O, Loewith R, Stokoe D, Balla A, Toth B, Balla T, Weiss WA, Williams RL, Shokat KM
Cell, 2006 May 19; 125 (4): 733-747
DOI: 10.1016/j.cell.2006.03.035
TOR signaling in growth and metabolism.
Wullschleger S, Loewith R, Hall MN
Cell, 2006 Feb 10; 124 (3): 471-484
DOI: 10.1016/j.cell.2006.01.016
The TOR signalling network from yeast to man.
De Virgilio C, Loewith R
Int J Biochem Cell Biol, 2006; 38 (9): 1476-1481
DOI: 10.1016/j.biocel.2006.02.013
2005
2005
Molecular organization of target of rapamycin complex 2.
Wullschleger S, Loewith R, Oppliger W, Hall MN
J Biol Chem, 2005 Sep 2; 280 (35): 30697-30704
Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization.
Kamada Y, Fujioka Y, Suzuki NN, Inagaki F, Wullschleger S, Loewith R, Hall MN, Ohsumi Y
Mol Cell Biol, 2005 Aug; 25 (16): 7239-7248
DOI: 10.1128/MCB.25.16.7239-7248.2005
2004
2004
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive.
Jacinto E, Loewith R, Schmidt A, Lin S, Rüegg MA, Hall A, Hall MN
Nat Cell Biol, 2004 Nov; 6 (11): 1122-1128
DOI: 10.1038/ncb1183
Genome-wide lethality screen identifies new PI4,5P2 effectors that regulate the actin cytoskeleton.
Audhya A, Loewith R, Parsons AB, Gao L, Tabuchi M, Zhou H, Boone C, Hall MN, Emr SD
EMBO J, 2004 Oct 1; 23 (19): 3747-3757
2002
2002
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control.
Loewith R, Jacinto E, Wullschleger S, Lorberg A, Crespo JL, Bonenfant D, Oppliger W, Jenoe P, Hall MN
Mol Cell, 2002 Sep; 10 (3): 457-468
DOI: 10.1016/s1097-2765(02)00636-6
Human ING1 proteins differentially regulate histone acetylation.
Vieyra D, Loewith R, Scott M, Bonnefin P, Boisvert FM, Cheema P, Pastyryeva S, Meijer M, Johnston RN, Bazett-Jones DP, McMahon S, Cole MD, Young D, Riabowol K
J Biol Chem, 2002 Aug 16; 277 (33): 29832-29839
2001
2001
Pho23 is associated with the Rpd3 histone deacetylase and is required for its normal function in regulation of gene expression and silencing in Saccharomyces cerevisiae.
Loewith R, Smith JS, Meijer M, Williams TJ, Bachman N, Boeke JD, Young D
J Biol Chem, 2001 Jun 29; 276 (26): 24068-24074
2000
2000
Three yeast proteins related to the human candidate tumor suppressor p33(ING1) are associated with histone acetyltransferase activities.
Loewith R, Meijer M, Lees-Miller SP, Riabowol K, Young D
Mol Cell Biol, 2000 Jun; 20 (11): 3807-3816
DOI: 10.1128/MCB.20.11.3807-3816.2000
Skh1, the MEK component of the mkh1 signaling pathway in Schizosaccharomyces pombe.
Loewith R, Hubberstey A, Young D
J Cell Sci, 2000 Jan; 113 ( Pt 1) : 153-160
1996
1996
Mammalian CAP interacts with CAP, CAP2, and actin.
Hubberstey A, Yu G, Loewith R, Lakusta C, Young D
J Cell Biochem, 1996 Jun 1; 61 (3): 459-466
DOI: 10.1002/(SICI)1097-4644(19960601)61:3%3C459::AID-JCB13%3E3.0.CO;2-E
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